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The excitatory neurons of the medial prefrontal cortex (mPFC) respond to social stimuli. However, little is known about how the neural activity is altered during social avoidance, and whether it could act as a target of low-intensity focused ultrasound stimulation (LIFUS) to rescue social deficits. The present study aimed to investigate the mechanisms of neuronal activities and inflammatory responses underlying the effect of LIFUS on social avoidance. We found that chronic LIFUS stimulation can effectively improve social avoidance in the defeated mice. Calcium imaging recordings by fiber photometry in the defeated mice showed inhibited ensemble activity during social behaviors. LIFUS instantaneously triggered the mPFC neuronal activities, and chronic LIFUS significantly enhanced their neuronal excitation related to social interactions. We further found that the excessive activation of microglial cells and the overexpression of the inflammation signaling, i.e. Toll-like receptors(TLR4)/nuclear factor-kappaB(NF-КB), in mPFC were significantly inhibited by LIFUS. These results suggest that the LIFUS may inhibit social avoidance behavior by reducing activation of the inflammatory response, increasing neuronal excitation, and protecting the integrity of the neuronal structure in the mPFC. Our findings raised the possibility of LIFUS being applied as novel neuromodulation for social avoidance treatment in neuropsychiatric diseases.

 

We observe spin transfer within a nondegenerate heteronuclear spinor atomic gas comprising a small 7Li population admixed with a 87Rb bath, with both elements in their F = 1 hyperfine spin manifolds. Prepared in a nonequilibrium initial state, the 7Li spin distribution evolves through incoherent spin-changing collisions toward a steady-state distribution. We identify and measure the cross sections of all three types of spin-dependent heteronuclear collisions, namely the spin-exchange, spin-mixing, and quadrupole-exchange interactions, and find agreement with predictions of heteronuclear 7Li - 87Rb interactions at low energy. Moreover, we observe that the steady state of the 7Li spinor gas can be controlled by varying the composition of the 87Rb spin bath with which it interacts.